MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Contact Details

Department of Asthma, Allergy & Respiratory Science

5th Floor, Thomas Guy House

Kings College London

Guys Hospital

London SE1 9RT

Telephone

020 7188 0603

Email

paul.lavender@kcl.ac.uk

Profile

Work in our laboratory focuses on how cells attain a chromatin environment that permits expression of the appropriate complement of genes and whether that environment is disrupted in disease states. We use Chromatin Immunoprecipitation (ChIP) and either deep sequencing or tiling array readouts to undertake unbiased analysis of transcription factor recruitment and modified histone enrichment which are either focussed on specific gene loci or studied genome-wide. In collaboration with Dr. David Cousins we have undertaken genome–wide studies of modified histone enrichments in Th1 and Th2 cells. We are particularly interested in the role that glucocorticoids have in regulating gene expression in the immune system and in structural cells implicated in asthma, and how their expression is perturbed in steroid resistance. We also study the transcriptomes of immune and structural cells where our goal is to identify key regulatory genes and pathways that mediate the effects of steroids.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Last modified: 04 December 2009 11:38