MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Contact Details

Asthma, Allergy & Respiratory Science

5th Floor, Tower Wing

Guy's Hospital

London

SE19RT

Telephone

Email: ying.sun@kcl.ac.uk

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We have been focusing on several studies including 1) Th2 cells in asthmatic inflammation; 2) Intrinsic and extrinsic asthma; 3) Cytokines and Chemokines in asthmatic airways and allergic inflammation; 4) Aspirin sensitive asthma; 5) Eosinophils and other mediators in remodelling in asthma and 6) new molecules in asthma, COPD and airways remodelling. We have made fundamental inroads in the investigation of the role of Th-2 cells, Th-2 cytokines, Th-2 attracting chemokines, PGE2 and other mediators in asthma and other allergic inflammation, with tangible clinical consequences, and on the cellular and molecular pathology of severe phenotypes of asthma, including intrinsic asthma, glucocorticoid resistant and aspirin sensitive disease. We have fundamentally contributed in these areas and published over 100 peer reviewed papers since 1991. We are currently interested in some novel molecules such as complement components, IL-17E (IL-25), FIZZ-2/RELM-beta and their receptors; investigate their roles in airways inflammation and remodelling. Our intention is to continue to develop laboratory-clinical based research in asthma and allergy. We believe that the fully understanding of these molecules and their roles in asthma and COPD will lead to development of novel targets for therapy of asthma and COPD.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Last modified: 04 December 2009 11:38