MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Contact Details

Leukocyte Biology Section, Division of Biomedical Sciences

Sir Alexander Fleming Building

South Kensington

Imperial College London

London

SW7 2AZ

Telephone

Email

s.saglani@imperial.ac.uk

Profile

Having obtained her undergraduate degree in medicine, Dr Saglani completed sub-specialist training in respiratory paediatrics in 2006, during which she obtained an MD in the pathology of infant and preschool wheeze. Subsequent to completing her sub-specialty training, she obtained a British Lung Foundation Research Fellowship to develop a neonatal mouse model of allergic airways disease. The establishment of this model has allowed her to obtain a Wellcome Intermediate Clinical Fellowship for her current work, under the mentorship of Professor Clare Lloyd and Professor Andrew Bush. Dr Saglani’s research interests include the pathology of infant and preschool wheeze, mechanisms of onset of airway remodelling in severe preschool wheeze, and disease modifying therapies for preschool wheeze and childhood difficult asthma. Increased tissue eosinophilic inflammation and reticular basement membrane (RBM) thickening (a feature of airway remodelling) are both present in preschool children with severe, recurrent wheeze, and a positive relationship is apparent between both pathological features. A reduction in eosinophilia may therefore allow an early reduction in the development of airway remodelling in these children, who are at high risk of developing severe childhood asthma.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Last modified: 04 December 2009 11:38