MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Contact Details

National Heart and Lung Institute

Guy Scadding Building

Royal Brompton Campus

Telephone

020 7352 8121

Email

m.moffatt@imperial.ac.uk

Profile

Professor Moffatt has worked in the field of genetics for the past 20 years, with a focus on the allergic diseases, asthma and atopic dermatitis. She has been extensively involved in both genome screens and positional cloning projects that have resulted in successful identification of loci influencing asthma and immunoglobulin E. She has also led or been involved in a number of candidate gene studies for asthma and atopic dermatitis which have led to identification of the susceptibility genes FCERIB, HLA, TCRA/D, TNF, NOD1, PDCD1 and SPINK5. Her studies have resulted in publications in high-impact journals.
Professor Moffatt has led genetic studies for Phase II of the International Studies of Asthma and Allergies in Childhood (ISAAC). These initial studies have now extended through the FP6 funded GABRIEL project (www.gabriel-fp6.org). Professor Moffatt co-leads (with Professor Bill Cookson) the Molecular Genetics Section at the National Heart and Lung Institute in London. She is currently leading a collaborative project with the CNG which has conducted whole genome wide association studies (GWAS) as well as eQTL analysis for both asthma and atopic dermatitis. In addition she is conducting studies into the role of epigenetics in asthma and atopic dermatitis as well as being involved in a number of metagenomics projects for respiratory diseases. She is a principal investigator in the Centre for Respiratory Infections at Imperial College (http://www1.imperial.ac.uk/medicine/about/institutes/centre_respiratory_infection/) as well as being involved with Professors Fan Chung and Ian Adcock in the IMI EU/EFPIA UBIOPRED project on Systems Biology of severe asthma (http://www.ubiopred.european-lung-foundation.org/).
Most recently Professor Moffatt has been co-first author on genome-wide association papers in Nature and Nature Genetics that describe finding of a major new asthma susceptibility gene, and a GWAS for global gene expression.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

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Last modified: 04 December 2009 11:38