Our Research Programmes

Leukocyte trafficking, chronic inflammation and airway structure

Allergic individuals develop inflammatory reactions at the site of exposure to allergens. The inflammation is manifest as dilation of small blood vessels resulting in increased local blood flow, leakage of plasma causing tissue swelling, and the accumulation of specific types of white blood cells. We are particularly interested in the mechanisms underlying the recruitment of these leukocytes and their influence on the affected tissues.

Group Leaders, research areas, departmental affiliations and all sources of recent funding

Randall Division of Cell and Molecular Biophysics, Guy’s, KCLfds
Biophysics; IgE structure and function
Recent funding:MRC, Asthma UK

Sir Alexander Fleming Building, Leukocyte Biology, Imperial
Eosinophil and T cell functions in allergy and asthma; clinical research
Recent funding:MRC (COG, component), Novartis, Millenium, Imperial College Trust, Powderject Plc, GSK

Dept of Asthma, Allergy and Respiratory Science
Molecular regulation of Th2 cytokines; glucocorticoid action and resistance; leukotriene biology; clinical research
Recent funding:MRC (JREI, Programme, component), Asthma UK

Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial
Animal models of allergic airway inflammation and remodelling
Recent funding:Wellcome Trust, BBSRC, Domantis Ltd, Oxford Glycosciences (UK) Ltd, MRC

Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial
Mediators and receptors responsible for leukocyte trafficking in allergic disease
Recent funding:Wellcome Trust, Asthma UK
He will act as research coordinator for this programme on inflammation

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

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Last modified: 21 May 2008 14:22