Our Research Programmes

Immunomodulation and prevention of respiratory morbidity

Downregulation of allergen driven Th2 cytokine production in disease represents a major goal to provide antigen-specific, long-term relief/cure of allergic symptoms. Allergen desensitisation immunotherapy was first described by workers at St Mary’s Hospital nearly 100 years ago and is currently the only effective disease modifying treatment for allergic disease although the mechanisms accounting for its efficacy are not fully understood and there is scope for improvement of this therapy with respect to both efficacy and safety.

Group Leaders, research areas, departmental affiliations and all sources of recent funding

Lung Immunology Group, Department of Biological Sciences, National Heart & Lung Institute, Imperial
Transgenic models.
Recent funding:MRC, The Welton Foundation, NHLI Foundation, Asthma UK

Dept. of Allergy & Clinical Immunology, National Heart and Lung Institute, Imperial
Immunotherapy and IgE regulation; clinical research
Recent funding:MRC (ROPA, project, COG, component), Asthma UK, NIH, GSK, EU, ALK
He will act as research coordinator for clinical studies in immunomodulation.

Dept Asthma, Allergy and Respiratory Science, Guy’s, KCL
Biology of drug-induced regulatory T cells and IL-10
Recent funding:Asthma UK, EU, MRC (project, CASE), Novartis, GSK
She will act as research coordinator for the programme on regulatory T cells

Allergy & Clinical Immunology, National Heart & Lung Institute, Imperial
Biology of T cell peptides and their use in immunotherapy
Recent funding:MRC(COG, component), Asthma UK, Imperial College Trust, Powderject Plc
He will act as research coordinator for the non-clinical programme on immunomodulation.

Dept Asthma, Allergy & Respiratory Science, Denmark Hill Campus, KCL
Immune regulation by CD8 T cell subsets
Recent funding:Asthma UK, MRC (career establishment), BBSRC

Leukocyte Biology Section, Allergy & Clinical Immunology, National Heart and Lung Institute, Imperial
Biology of naturally occurring CD4+ CD25+ regulatory T cells; clinical research
Recent funding:Wellcome Trust, Asthma UK, MRC (COG, component), GSK National Kidney Research Fund, GSK

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

About the Centre | Our Mission | Our Research | Contact Us | Directions

About King's College London | About Imperial College London | About the MRC | About Asthma UK

Last modified: 21 May 2008 14:22