IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis.

TitleIFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis.
Publication TypeJournal Article
Year of Publication2006
AuthorsBoyton RJ, Reynolds C, Wahid FN, Jones MG, Ozerovitch L, Ahmad T, Chaudhry A, Jewell DP, Kon OM, Smith J, Rose M, Newman-Taylor AJ, Cole P, Wilson R, Altmann DM
JournalTissue Antigens
Volume68
Issue4
Pagination325-30
Date Published2006 Oct
ISSN0001-2815
KeywordsAlleles, Bronchiectasis, Colitis, Ulcerative, Female, Genetic Predisposition to Disease, Genotype, Humans, Interferon-gamma, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Interleukin-8A
Abstract

Idiopathic bronchiectasis is a disease of chronic, bacterial lung infection, unresolving inflammation and progressive lung damage. Bronchiectasis can be associated with autoimmune diseases including ulcerative colitis. Defects of both innate and adaptive immunity have been proposed. The airway inflammation is characterized by interleukin-8 (IL-8) expression and infiltration by neutrophils and T cells. Here we investigated two candidate gene polymorphisms that may contribute to disease susceptibility: a CXCR-1 (+2607 G/C) gene polymorphism that is implicated in IL-8 binding and neutrophil trafficking as well as the interferon-gamma (IFNgamma) (+874 T/A) polymorphism which is linked to levels of IFNgamma production. These polymorphisms were distributed similarly in the idiopathic bronchiectasis group and controls, suggesting that these two candidate gene polymorphisms are not associated with disease susceptibility.

DOI10.1111/j.1399-0039.2006.00670.x
Alternate JournalTissue Antigens
PubMed ID17026468

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