Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

TitleAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Publication TypeJournal Article
Year of Publication2010
AuthorsSpeliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HLango, Lindgren CM, Luan J'an, Mägi R et al.
Corporate AuthorsMAGIC, Procardis Consortium
JournalNat Genet
Volume42
Issue11
Pagination937-48
Date Published2010 Nov
ISSN1546-1718
KeywordsBody Height, Body Mass Index, Body Size, Body Weight, Chromosome Mapping, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Obesity, Polymorphism, Single Nucleotide
Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

DOI10.1038/ng.686
Alternate JournalNat. Genet.
PubMed ID20935630
PubMed Central IDPMC3014648
Grant List064890 / / Wellcome Trust / United Kingdom
068545 / / Wellcome Trust / United Kingdom
072960 / / Wellcome Trust / United Kingdom
075491 / / Wellcome Trust / United Kingdom
076113 / / Wellcome Trust / United Kingdom
077016 / / Wellcome Trust / United Kingdom
079557 / / Wellcome Trust / United Kingdom
079557 / / Wellcome Trust / United Kingdom
079895 / / Wellcome Trust / United Kingdom
081682 / / Wellcome Trust / United Kingdom
081682 / / Wellcome Trust / United Kingdom
083270 / / Wellcome Trust / United Kingdom
085301 / / Wellcome Trust / United Kingdom
086596 / / Wellcome Trust / United Kingdom
263-MA-410953 / / PHS HHS / United States
AA014041 / AA / NIAAA NIH HHS / United States
AA07535 / AA / NIAAA NIH HHS / United States
AA10248 / AA / NIAAA NIH HHS / United States
AA13320 / AA / NIAAA NIH HHS / United States
AA13321 / AA / NIAAA NIH HHS / United States
AA13326 / AA / NIAAA NIH HHS / United States
CA047988 / CA / NCI NIH HHS / United States
CA49449 / CA / NCI NIH HHS / United States
CA50385 / CA / NCI NIH HHS / United States
CA65725 / CA / NCI NIH HHS / United States
CA67262 / CA / NCI NIH HHS / United States
CA87969 / CA / NCI NIH HHS / United States
DA12854 / DA / NIDA NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
DK072193 / DK / NIDDK NIH HHS / United States
DK46200 / DK / NIDDK NIH HHS / United States
DK58845 / DK / NIDDK NIH HHS / United States
F32 DK079466-01 / DK / NIDDK NIH HHS / United States
HG002651 / HG / NHGRI NIH HHS / United States
HL084729 / HL / NHLBI NIH HHS / United States
HL71981 / HL / NHLBI NIH HHS / United States
K05 AA017688-04 / AA / NIAAA NIH HHS / United States
K08 AR055688-03 / AR / NIAMS NIH HHS / United States
K08 AR055688-04 / AR / NIAMS NIH HHS / United States
K23 DK080145-01 / DK / NIDDK NIH HHS / United States
K23-DK080145 / DK / NIDDK NIH HHS / United States
K99-HL094535 / HL / NHLBI NIH HHS / United States
M01-RR00425 / RR / NCRR NIH HHS / United States
MH084698 / MH / NIMH NIH HHS / United States
N01-AG12100 / AG / NIA NIH HHS / United States
N01-AG12109 / AG / NIA NIH HHS / United States
N01-HC15103 / HC / NHLBI NIH HHS / United States
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N01-HC45133 / HC / NHLBI NIH HHS / United States
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R01-HL086694 / HL / NHLBI NIH HHS / United States
R01-HL087641 / HL / NHLBI NIH HHS / United States
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R01-HL087652 / HL / NHLBI NIH HHS / United States
R01-HL087676 / HL / NHLBI NIH HHS / United States
R01-HL087679 / HL / NHLBI NIH HHS / United States
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R01-HL088119 / HL / NHLBI NIH HHS / United States
R01-HL59367 / HL / NHLBI NIH HHS / United States
R01-MH59160 / MH / NIMH NIH HHS / United States
R01-MH59565 / MH / NIMH NIH HHS / United States
R01-MH59566 / MH / NIMH NIH HHS / United States
R01-MH59571 / MH / NIMH NIH HHS / United States
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R01-MH81800 / MH / NIMH NIH HHS / United States
R01DK068336 / DK / NIDDK NIH HHS / United States
R01DK075681 / DK / NIDDK NIH HHS / United States
RL1-MH083268 / MH / NIMH NIH HHS / United States
T32 GM074905 / GM / NIGMS NIH HHS / United States
T32 HG000040 / HG / NHGRI NIH HHS / United States
T32 HG000040-17 / HG / NHGRI NIH HHS / United States
T32-HG00040 / HG / NHGRI NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
U01 DK062370-08 / DK / NIDDK NIH HHS / United States
U01-CA098233 / CA / NCI NIH HHS / United States
U01-DK062418 / DK / NIDDK NIH HHS / United States
U01-GM074518 / GM / NIGMS NIH HHS / United States
U01-HG004399 / HG / NHGRI NIH HHS / United States
U01-HG004402 / HG / NHGRI NIH HHS / United States
U01-HL080295 / HL / NHLBI NIH HHS / United States
U01-HL084756 / HL / NHLBI NIH HHS / United States
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U54-RR020278 / RR / NCRR NIH HHS / United States
UL1-RR025005 / RR / NCRR NIH HHS / United States
Z01-HG000024 / HG / NHGRI NIH HHS / United States
/ / British Heart Foundation / United Kingdom
/ / Cancer Research UK / United Kingdom
/ / Department of Health / United Kingdom

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