Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

TitleGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Publication TypeJournal Article
Year of Publication2011
AuthorsEhret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang S-J et al.
Corporate AuthorsInternational Consortium for Blood Pressure Genome-Wide Association Studies, CARDIoGRAM consortium, CKDGen consortium, KidneyGen consortium, EchoGen consortium, CHARGE-HF consortium
JournalNature
Volume478
Issue7367
Pagination103-9
Date Published2011 Oct 6
ISSN1476-4687
KeywordsAfrica, Asia, Blood Pressure, Cardiovascular Diseases, Coronary Artery Disease, Europe, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Kidney Diseases, Polymorphism, Single Nucleotide, Stroke
Abstract

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

DOI10.1038/nature10405
Alternate JournalNature
PubMed ID21909115
PubMed Central IDPMC3340926
Grant List068545/Z/02 / / Wellcome Trust / United Kingdom
070191/Z/03/Z / / Wellcome Trust / United Kingdom
077016/Z/05/Z / / Wellcome Trust / United Kingdom
079895 / / Wellcome Trust / United Kingdom
080747/Z/06/Z / / Wellcome Trust / United Kingdom
1R01AG032098-01A / AG / NIA NIH HHS / United States
1RL1MH083268-01 / MH / NIMH NIH HHS / United States
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263-MA-410953 / / PHS HHS / United States
2M01RR010284 / RR / NCRR NIH HHS / United States
33014 / / PHS HHS / United States
55005617 / / Howard Hughes Medical Institute / United States
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AG13196 / AG / NIA NIH HHS / United States
CH/03/001 / / British Heart Foundation / United Kingdom
CZB/4/276 / / Chief Scientist Office / United Kingdom
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