Human risk assessment of heavy metals: principles and applications.

TitleHuman risk assessment of heavy metals: principles and applications.
Publication TypeJournal Article
Year of Publication2011
AuthorsDorne J-LCM, Kass GEN, Bordajandi LR, Amzal B, Bertelsen U, Castoldi AF, Heppner C, Eskola M, Fabiansson S, Ferrari P, Scaravelli E, Dogliotti E, Fuerst P, Boobis AR, Verger P
JournalMet Ions Life Sci
Volume8
Pagination27-60
Date Published2011
ISSN1559-0836
KeywordsArsenic, Cadmium, Carcinogens, Environmental Exposure, Environmental Pollutants, Food Safety, Humans, Mercury, Metalloids, Metals, Heavy, Pharmacokinetics, Risk Assessment, Uranium, World Health Organization
Abstract

Humans are exposed to a number of "heavy metals" such as cadmium, mercury and its organic form methylmercury, uranium, lead, and other metals as wel as metalloids, such as arsenic, in the environment, workplace, food, and water supply. Exposure to these metals may result in adverse health effects, and national and international health agencies have methodologies to set health-based guidance values with the aim to protect the human population. This chapter introduces the general principles of chemical risk assessment, the common four steps of chemical risk assessment: hazard identification, hazard characterization, exposure assessment, risk characterization, and toxicokinetic and toxicity aspects. Finally, the risk assessments performed by international health agencies such as the World Health Organisation, the Environmental Protection Agency of the United States, and the European Food Safety Authority are reviewed for cadmium, lead, mercury, uranium, and arsenic.

Alternate JournalMet Ions Life Sci
PubMed ID21473375

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