Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.

TitleSevere asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.
Publication TypeJournal Article
Year of Publication2012
AuthorsJarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung K F, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague GW, Wenzel SE, Busse WW
Corporate AuthorsNHLBI Severe Asthma Research Program(SARP)
JournalAm J Respir Crit Care Med
Volume185
Issue4
Pagination356-62
Date Published2012 Feb 15
ISSN1535-4970
KeywordsAdolescent, Adult, Airway Remodeling, Asthma, Biological Markers, Bronchoscopy, Child, Clinical Protocols, Cohort Studies, Cross-Sectional Studies, Humans, Risk Factors, Severity of Illness Index
Abstract

The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.

DOI10.1164/rccm.201107-1317PP
Alternate JournalAm. J. Respir. Crit. Care Med.
PubMed ID22095547
PubMed Central IDPMC3297096
Grant List1UL1RR024989 / RR / NCRR NIH HHS / United States
1UL1RR024992 / RR / NCRR NIH HHS / United States
1UL1RR025011 / RR / NCRR NIH HHS / United States
HL091762 / HL / NHLBI NIH HHS / United States
HL69116 / HL / NHLBI NIH HHS / United States
HL69130 / HL / NHLBI NIH HHS / United States
HL69155 / HL / NHLBI NIH HHS / United States
HL69167 / HL / NHLBI NIH HHS / United States
HL69170 / HL / NHLBI NIH HHS / United States
HL69174 / HL / NHLBI NIH HHS / United States
HL69349 / HL / NHLBI NIH HHS / United States
M01 RR007122-14 / RR / NCRR NIH HHS / United States
M01 RR03186 / RR / NCRR NIH HHS / United States
UL1 RR024989 / RR / NCRR NIH HHS / United States
UL1 RR024992 / RR / NCRR NIH HHS / United States
UL1 TR000427 / TR / NCATS NIH HHS / United States

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